Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

De Nucci, Gilberto; Thomas, Ranjeny; D’Orléans-Juste, Pedro; Antunes, Edson; E. Walder, Claire; D. Warner, Timothy; R. Vane, John

doi:10.1073/pnas.85.24.9797

Public

Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.

Published in Proceedings of the National Academy of Sciences • Dec 1, 1988

Authors:

Gilberto De Nucci

Ranjeny Thomas

Pedro D’Orléans-Juste

Abstract

Endothelin releases prostacyclin and thromboxane A2 from guinea pig or rat isolated lungs and endothelium-derived relaxing factor in the perfused mesentery of the rat. Endothelin is also substantially removed by the pulmonary circulation of the rat in vitro and in vivo and by guinea pig lungs in vit...

Subject

Prostacyclin

Endocrinology

Internal medicine

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