Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

Xiao, Mengtao; Yang, Hui; Xu, Wei; Ma, Shenghong; Lin, Huaipeng; Zhu, Honguang; Liu, Lixia; Liu, Ying; Chen, Yang; Xu, Yanhui; Zhao, Shimin; Ye, Dan; Xiong, Yue; Guan, Kun‐Liang

doi:10.1101/gad.191056.112

Public

Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

Published in Genes & Development • Jun 7, 2012

Authors:

Mengtao Xiao

Hui Yang

Wei Xu

Abstract

Two Krebs cycle genes, fumarate hydratase (FH) and succinate dehydrogenase (SDH), are mutated in a subset of human cancers, leading to accumulation of their substrates, fumarate and succinate, respectively. Here we demonstrate that fumarate and succinate are competitive inhibitors of multiple α-keto...

Subject

Biology

Fumarase

Succinate dehydrogenase

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