A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

Kappos, Ludwig; Radue, Ernst‐Wilhelm; O’Connor, Paul; H. Polman, Chris; Hohlfeld, Reinhard; A. Calabresi, Peter; Selmaj, Krzysztof; Agoropoulou, Catherine; Leyk, Małgorzata; Zhang-Auberson, Lixin; Burtin, P

doi:10.1056/nejmoa0909494

Public

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

Published in New England Journal of Medicine • Jan 20, 2010

Authors:

Ludwig Kappos

Ernst‐Wilhelm Radue

Paul O’Connor

Abstract

BACKGROUND: Oral fingolimod, a sphingosine-1-phosphate-receptor modulator that prevents the egress of lymphocytes from lymph nodes, significantly improved relapse rates and end points measured on magnetic resonance imaging (MRI), as compared with either placebo or intramuscular interferon beta-1a, i...

Subject

Fingolimod

Medicine

Multiple sclerosis

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