Paracrine <i>in vivo</i> inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: An alternative mechanism of HBx-related pathogenesis

Guilherme Tralhão, José; Roudier, Jean; Morosan, Serban; Giannini, Carlo; Tu, Hong; Goulenok, Cyril; Carnot, Françoise; Zavala, Flora; Joulin, V.; Kremsdorf, Dina; Bréchot, Christian

doi:10.1073/pnas.092657699

Public

Paracrine in vivo inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: An alternative mechanism of HBx-related pathogenesis

Published in Proceedings of the National Academy of Sciences • May 14, 2002

Authors:

José Guilherme Tralhão

Jean Roudier

Serban Morosan

Abstract

The role of the hepatitis B virus X protein (HBx) in the pathogenesis of hepatitis B virus (HBV) infection remains unclear. HBx exhibits pleiotropic biological effects, whose in vivo relevance is a matter for debate. In the present report, we have used a combination of HBx-expressing transgenic mice...

Subject

HBx

Paracrine signalling

Biology

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