Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

Y. T. Chien, Ellen; Liu, Wei; Zhao, Qiang; Katritch, Vsevolod; Won Han, Gye; A. Hanson, Michael; Shi, Lei; Hauck Newman, Amy; A. Javitch, Jonathan; Cherezov, Vadim; C. Stevens, Raymond

doi:10.1126/science.1197410

Public

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

Shared by NobleBlocks on Nov 19, 2010 • 12:00 AM UTC

Authors:

Ellen Y. T. Chien

Wei Liu

Qiang Zhao

Abstract

Tweaking Dopamine Reception Dopamine modulates many cognitive and emotional functions of the human brain by activating G protein–coupled receptors. Antipsychotic drugs that block two of the receptor subtypes are used to treat schizophrenia but have multiple side effects. Chien et al. (p. 1091 ; see ...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!