Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

Y. T. Chien, Ellen; Liu, Wei; Zhao, Qiang; Katritch, Vsevolod; Won Han, Gye; A. Hanson, Michael; Shi, Lei; Hauck Newman, Amy; A. Javitch, Jonathan; Cherezov, Vadim; C. Stevens, Raymond

doi:10.1126/science.1197410

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Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

Published in Science • Nov 18, 2010

Authors:

Ellen Y. T. Chien

Wei Liu

Qiang Zhao

Abstract

Dopamine modulates movement, cognition, and emotion through activation of dopamine G protein-coupled receptors in the brain. The crystal structure of the human dopamine D3 receptor (D3R) in complex with the small molecule D2R/D3R-specific antagonist eticlopride reveals important features of the liga...

Subject

Dopamine receptor D3

Receptor

Dopamine receptor D2

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