DISC1 and PDE4B Are Interacting Genetic Factors in Schizophrenia That Regulate cAMP Signaling

Kirsty Millar, J.; Pickard, Ben; Mackie, Shaun; James, Rachel; Christie, Sheila; R. Buchanan, Sebastienne; P. Malloy, M.; E. Chubb, Jennifer; Huston, Elaine; S. Baillie, George; A. Thomson, Pippa; V. Hill, Elaine; J. Brandon, Nicholas; Rain, Jean‐Christophe; Miguel Camargo, Luiz; J. Whiting, Paul; D. Houslay, Miles; Blackwood, Douglas; Muir, Walter; J. Porteous, David

doi:10.1126/science.1112915

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DISC1 and PDE4B Are Interacting Genetic Factors in Schizophrenia That Regulate cAMP Signaling

Published in Science • Nov 18, 2005

Authors:

J. Kirsty Millar

Ben Pickard

Shaun Mackie

Abstract

The disrupted in schizophrenia 1 (DISC1) gene is a candidate susceptibility factor for schizophrenia, but its mechanistic role in the disorder is unknown. Here we report that the gene encoding phosphodiesterase 4B (PDE4B) is disrupted by a balanced translocation in a subject diagnosed with schizophr...

Subject

DISC1

Schizophrenia (object-oriented programming)

Phosphodiesterase

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