Histone Deacetylase 3 (HDAC3) and Other Class I HDACs Regulate Colon Cell Maturation and p21 Expression and Are Deregulated in Human Colon Cancer

J. Wilson, Andrew; Byun, Do-Sun; В. Попова, Н.; B. Murray, Lucas; E. L’Italien, Kaitlin; Sowa, Yoshihiro; Arango, Diego; Velcich, Anna; H. Augenlicht, Leonard; M. Mariadason, John

doi:10.1074/jbc.m510023200

Public

Histone Deacetylase 3 (HDAC3) and Other Class I HDACs Regulate Colon Cell Maturation and p21 Expression and Are Deregulated in Human Colon Cancer

Published in Journal of Biological Chemistry • Mar 14, 2006

Authors:

Andrew J. Wilson

Do-Sun Byun

Н. В. Попова

Abstract

Inhibitors of histone deacetylases (HDACs) induce growth arrest, differentiation, and apoptosis of colon cancer cell lines in vitro and have demonstrated anti-cancer efficacy in clinical trials. Whereas a role for HDAC1 and -2 in mediating components of the HDAC inhibitor response has been reported,...

Subject

HDAC3

Gene silencing

Histone deacetylase 2

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!