DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes

Kuramochi‐Miyagawa, Satomi; Watanabe, Toshiaki; Gotoh, Kengo; Totoki, Yasushi; Toyoda, Atsushi; Ikawa, Masahito; Asada, Noriko; Kojima, Kanako; Yamaguchi, Yuka; W. Ijiri, Takashi; Hata, Kenichiro; Li, En; Matsuda, Yoichi; Kimura, Tohru; Okabe, Masaru; Sakaki, Yoshiyuki; Sasaki, Hiroyuki; Nakano, Toru

doi:10.1101/gad.1640708

Public

DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes

Published in Genes & Development • Apr 1, 2008

Authors:

Satomi Kuramochi‐Miyagawa

Toshiaki Watanabe

Kengo Gotoh

Abstract

Silencing of transposable elements occurs during fetal gametogenesis in males via de novo DNA methylation of their regulatory regions. The loss of MILI (miwi-like) and MIWI2 (mouse piwi 2), two mouse homologs of Drosophila Piwi, activates retrotransposon gene expression by impairing DNA methylation ...

Subject

Biology

Piwi-interacting RNA

Retrotransposon

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