<i>MGMT</i> Gene Silencing and Benefit from Temozolomide in Glioblastoma

E. Hegi, Monika; Diserens, Annie‐Claire; Gorlia, Thierry; Hamou, Marie‐France; de Tribolet, Nicolas; Weller, Michael; M. Kros, Johan; A. Hainfellner, Johannes; Mason, Warren; Mariani, Luigi; E. C. Bromberg, Jacoline; Hau, Peter; Mirimanoff, R.O.; Gregory Cairncross, J.; C. Janzer, Robert; Stupp, Roger

doi:10.1056/nejmoa043331

Public

MGMT Gene Silencing and Benefit from Temozolomide in Glioblastoma

Published in New England Journal of Medicine • Mar 9, 2005

Authors:

Monika E. Hegi

Annie‐Claire Diserens

Thierry Gorlia

Abstract

BACKGROUND: Epigenetic silencing of the MGMT (O6-methylguanine-DNA methyltransferase) DNA-repair gene by promoter methylation compromises DNA repair and has been associated with longer survival in patients with glioblastoma who receive alkylating agents. METHODS: We tested the relationship between M...

Subject

Temozolomide

Medicine

O-6-methylguanine-DNA methyltransferase

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