Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

J. Ferrante, Robert; K. Kubilus, James; Lee, Junghee; Ryu, Hoon; Ana Beesen, Ayshe; Zucker, Birgit; Smith, Karen; W. Kowall, Neil; R. Ratan, Rajiv; Luthi‐Carter, Ruth; M. Hersch, Steven

doi:10.1523/jneurosci.23-28-09418.2003

Public

Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

Published in Journal of Neuroscience • Oct 15, 2003

Authors:

Robert J. Ferrante

James K. Kubilus

Junghee Lee

Abstract

The precise cause of neuronal death in Huntington's disease (HD) is unknown. Although no single specific protein-protein interaction of mutant huntingtin has emerged as the pathologic trigger, transcriptional dysfunction may contribute to the neurodegeneration observed in HD. Pharmacological treatme...

Subject

Sodium butyrate

Histone deacetylase

Phenotype

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