Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

A. Grupp, Stephan; Kalos, Michael; M. Barrett, David; Aplenc, Richard; L. Porter, David; R. Rheingold, Susan; T. Teachey, David; Chew, Anne; Hauck, Bernd; Fraser Wright, J.; C. Milone, Michael; L. Levine, Bruce; H. June, Carl

doi:10.1056/nejmoa1215134

Public

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

Published in New England Journal of Medicine • Mar 25, 2013

Authors:

Stephan A. Grupp

Michael Kalos

David M. Barrett

Abstract

Chimeric antigen receptor-modified T cells with specificity for CD19 have shown promise in the treatment of chronic lymphocytic leukemia (CLL). It remains to be established whether chimeric antigen receptor T cells have clinical activity in acute lymphoblastic leukemia (ALL). Two children with relap...

Subject

Chimeric antigen receptor

Medicine

Cytokine release syndrome

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