Intraepithelial CD8 <sup>+</sup> tumor-infiltrating lymphocytes and a high CD8 <sup>+</sup> /regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

Sato, Eiichi; H. Olson, Sara; Ahn, Jiyoung; N. Bundy, Brian; Nishikawa, Hiroyoshi; Qian, Feng; A. Jungbluth, Achim; Frosina, Denise; Gnjatic, Sacha; B. Ambrosone, Christine; L. Kepner, James; Odunsi, Tosin; Ritter, Gerd; Lele, Shashikant; Chen, Yao‐Tseng; Ohtani, Haruo; J. Old, Lloyd; Odunsi, Kunle

doi:10.1073/pnas.0509182102

Public

Intraepithelial CD8 + tumor-infiltrating lymphocytes and a high CD8 + /regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

Published in Proceedings of the National Academy of Sciences • Dec 12, 2005

Authors:

Eiichi Sato

Sara H. Olson

Jiyoung Ahn

Abstract

In a recent report, [Zhang et al. (2003) N. Engl. J. Med. 348, 203-213], the presence of CD3+ tumor-infiltrating lymphocytes (TILs) was found to correlate with improved survival in epithelial ovarian cancer. We performed immunohistochemical analysis for TILs and cancer testis antigens in 117 cases o...

Subject

Hazard ratio

CD8

FOXP3

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