Myeloma Cell-Osteoclast Interaction Enhances Angiogenesis Together with Bone Resorption: A Role for Vascular Endothelial Cell Growth Factor and Osteopontin

Tanaka, Yoïchi; Abe, Masahiro; Hiasa, Masahiro; Oda, Asuka; Amou, Hiroe; Nakano, Ayako; Takeuchi, Kyoko; Kitazoe, Ken-ichi; Kido, Shinsuke; Inoue, Daisuke; Moriyama, Keiji; Hashimoto, Toshihiro; Ozaki, Shuji; Matsumoto, Toshio

doi:10.1158/1078-0432.ccr-06-2258

Public

Myeloma Cell-Osteoclast Interaction Enhances Angiogenesis Together with Bone Resorption: A Role for Vascular Endothelial Cell Growth Factor and Osteopontin

Published in Clinical Cancer Research • Feb 1, 2007

Authors:

Yoïchi Tanaka

Masahiro Abe

Masahiro Hiasa

Abstract

PURPOSE: Similar to osteoclastogenesis, angiogenesis is enhanced in the bone marrow in myeloma in parallel with tumor progression. We showed previously that myeloma cells and osteoclasts are mutually stimulated to form a vicious cycle to lead to enhance both osteoclastogenesis and tumor growth. The ...

Subject

Angiogenesis

Osteopontin

Osteoclast

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