Immune Infiltrates Are Prognostic Factors in Localized Gastrointestinal Stromal Tumors

Rusakiewicz, Sylvie; Semeraro, Michaëla; Sarabi, Matthieu; Desbois, Mélanie; Locher, Clara; Méndez, R.; Vimond, Nadège; Concha, Ángel; Garrido, Federico; Isambert, Nicolás; Chaigneau, L.; Le Brun-Ly, Valérie; Dubreuil, Patrice; Cremer, Isabelle; Caignard, Anne; Poirier-Colame, Vichnou; Chaba, Kariman; Flament, Caroline; Halama, Niels; Jäger, Dirk; Eggermont, Alexander; Bonvalot, Sylvie; Commo, Frédéric; Terrier, Philippe; Opolon, Paule; Emile, Jean‐François; Coindre, Jean‐Michel; Kroemer, Guido; Chaput, Nathalie; Le Cesne, Axel; Blay, Jean‐Yves; Zitvogel, Laurence

doi:10.1158/0008-5472.can-13-0371

Public

Immune Infiltrates Are Prognostic Factors in Localized Gastrointestinal Stromal Tumors

Published in Cancer Research • Apr 17, 2013

Authors:

Sylvie Rusakiewicz

Michaëla Semeraro

Matthieu Sarabi

Abstract

Cancer immunosurveillance relies on effector/memory tumor-infiltrating CD8(+) T cells with a T-helper cell 1 (TH1) profile. Evidence for a natural killer (NK) cell-based control of human malignancies is still largely missing. The KIT tyrosine kinase inhibitor imatinib mesylate markedly prolongs the ...

Subject

Immunosurveillance

GiST

Imatinib mesylate

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