Immune infiltrates are prognostic factors in localized gastrointestinal stromal tumors.

S, Rusakiewicz; M, Semeraro; M, Sarabi; M, Desbois; C, Locher; R, Mendez; N, Vimond; A, Concha; F, Garrido; N, Isambert; L, Chaigneau; Brun-Ly V, Le; P, Dubreuil; I, Cremer; A, Caignard; V, Poirier-Colame; K, Chaba; C, Flament; N, Halama; D, Jäger; A, Eggermont; S, Bonvalot; F, Commo; P, Terrier; P, Opolon; JF, Emile; JM, Coindre; G, Kroemer; N, Chaput; Cesne A, Le; JY, Blay; L, Zitvogel

doi:10.1158/0008-5472.can-13-0371

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Immune infiltrates are prognostic factors in localized gastrointestinal stromal tumors.

Shared by NobleBlocks on Apr 16, 2013 • 12:00 AM UTC

Authors:

Rusakiewicz S

Semeraro M

Sarabi M

Abstract

Cancer immunosurveillance relies on effector/memory tumor-infiltrating CD8(+) T cells with a T-helper cell 1 (TH1) profile. Evidence for a natural killer (NK) cell-based control of human malignancies is still largely missing. The KIT tyrosine kinase inhibitor imatinib mesylate markedly prolongs the ...

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