Molecular Properties That Influence the Oral Bioavailability of Drug Candidates

F. Veber, Daniel; R. Johnson, Stephen; Cheng, Hung‐Yuan; R. Smith, Brian; W. Ward, Keith; D. Kopple, Kenneth

doi:10.1021/jm020017n

Public

Molecular Properties That Influence the Oral Bioavailability of Drug Candidates

Published in Journal of Medicinal Chemistry • May 11, 2002

Authors:

Daniel F. Veber

Stephen R. Johnson

Hung‐Yuan Cheng

Abstract

Oral bioavailability measurements in rats for over 1100 drug candidates studied at SmithKline Beecham Pharmaceuticals (now GlaxoSmithKline) have allowed us to analyze the relative importance of molecular properties considered to influence that drug property. Reduced molecular flexibility, as measure...

Subject

Bioavailability

Chemistry

Polar surface area

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