Identification of Genes Periodically Expressed in the Human Cell Cycle and Their Expression in Tumors

L. Whitfield, Michael; Sherlock, Gavin; J. Saldanha, Alok; I. Murray, John; A. Ball, Catherine; E. Alexander, Karen; C. Matese, John; M. Perou, Charles; M. Hurt, Myra; O. Brown, Patrick; Botstein, David

doi:10.1091/mbc.02-02-0030

Public

Identification of Genes Periodically Expressed in the Human Cell Cycle and Their Expression in Tumors

Published in Molecular Biology of the Cell • Jun 1, 2002

Authors:

Michael L. Whitfield

Gavin Sherlock

Alok J. Saldanha

Abstract

The genome-wide program of gene expression during the cell division cycle in a human cancer cell line (HeLa) was characterized using cDNA microarrays. Transcripts of >850 genes showed periodic variation during the cell cycle. Hierarchical clustering of the expression patterns revealed coexpressed gr...

Subject

Biology

Cell cycle

Gene

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