In vivoTherapeutic Responses Contingent on Fanconi Anemia/BRCA2 Status of the Tumor

S. van der Heijden, Michiel; R. Brody, Jonathan; A. Dezentjé, David; Gallmeier, Eike; C. Cunningham, Steven; J. Swartz, Michael; M. De Marzo, Angelo; Johan A. Offerhaus, G.; H. Isacoff, William; H. Hruban, Ralph; E. Kern, Scott

doi:10.1158/1078-0432.ccr-05-1048

Public

In vivoTherapeutic Responses Contingent on Fanconi Anemia/BRCA2 Status of the Tumor

Published in Clinical Cancer Research • Oct 15, 2005

Authors:

Michiel S. van der Heijden

Jonathan R. Brody

David A. Dezentjé

Abstract

PURPOSE: BRCA2, FANCC, and FANCG gene mutations are present in a subset of pancreatic cancer. Defects in these genes could lead to hypersensitivity to interstrand cross-linkers in vivo and a more optimal treatment of pancreatic cancer patients based on the genetic profile of the tumor. EXPERIMENTAL ...

Subject

Fanconi anemia

Cancer research

Gemcitabine

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