Colistin Resistance in <i>Acinetobacter baumannii</i> Is Mediated by Complete Loss of Lipopolysaccharide Production

H. Moffatt, Jennifer; Harper, Marina; F. Harrison, Paul; Hale, John; Vinogradov, Evgeny; Seemann, Torsten; Henry, Rebekah; Crane, Bethany; St. Michael, Frank; D. Cox, Andrew; Adler, Ben; L. Nation, Roger; Li, Jian; D. Boyce, John

doi:10.1128/aac.00834-10

Public

Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production

Published in Antimicrobial Agents and Chemotherapy • Sep 21, 2010

Authors:

Jennifer H. Moffatt

Marina Harper

Paul F. Harrison

Abstract

Infections caused by multidrug-resistant (MDR) Gram-negative bacteria represent a major global health problem. Polymyxin antibiotics such as colistin have resurfaced as effective last-resort antimicrobials for use against MDR Gram-negative pathogens, including Acinetobacter baumannii. Here we show t...

Subject

Colistin

Acinetobacter baumannii

Polymyxin

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