Human tonsil B - cell lymphoma 6 ( BCL6 )-expressing CD4 + T-cell subset specialized for B-cell help outside germinal centers

Bentebibel, Salah-Eddine; Schmitt, Nathalie; Banchereau, Jacques; Ueno, Hideki

doi:10.1073/pnas.1100898108

Public

Human tonsil B - cell lymphoma 6 ( BCL6 )-expressing CD4 + T-cell subset specialized for B-cell help outside germinal centers

Published in Proceedings of the National Academy of Sciences • Aug 1, 2011

Authors:

Salah-Eddine Bentebibel

Nathalie Schmitt

Jacques Banchereau

Abstract

T follicular helper (Tfh) cells represent a Th subset engaged in the help of B-cell responses in germinal centers (GCs). Tfh cells abundantly express the transcription repressor B-cell lymphoma 6 (Bcl6), a factor that is necessary and sufficient for their development in vivo. Whether Tfh or Tfh-comm...

Subject

BCL6

CXCR5

Germinal center

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