A CD36-initiated Signaling Cascade Mediates Inflammatory Effects of β-Amyloid

J. Moore, Kathryn; El Khoury, Joseph; A. Medeiros, Lea; Terada, Kinya; Geula, Changiz; D. Luster, Andrew; W. Freeman, Mason

doi:10.1074/jbc.m208788200

Public

A CD36-initiated Signaling Cascade Mediates Inflammatory Effects of β-Amyloid

Published in Journal of Biological Chemistry • Nov 28, 2002

Authors:

Kathryn J. Moore

Joseph El Khoury

Lea A. Medeiros

Abstract

beta-Amyloid accumulation is associated with pathologic changes in the brain in Alzheimer's disease and has recently been identified in plaques of another chronic inflammatory disorder, atherosclerosis. The class B scavenger receptor, CD36, mediates binding of fibrillar beta-amyloid to cells of the ...

Subject

Cascade

Amyloid (mycology)

Inflammation

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