Immune correlates of vaccine protection against HIV-1 acquisition

Corey, Lawrence; B. Gilbert, Peter; D. Tomaras, Georgia; F. Haynes, Barton; Pantaleo, Giuseppe; S. Fauci, Anthony

doi:10.1126/scitranslmed.aac7732

Public

Immune correlates of vaccine protection against HIV-1 acquisition

Published in Science Translational Medicine • Oct 21, 2015

Authors:

Lawrence Corey

Peter B. Gilbert

Georgia D. Tomaras

Abstract

The partial efficacy reported in the RV144 HIV vaccine trial in 2009 has driven the HIV vaccine field to define correlates of risk associated with HIV-1 acquisition and connect these functionally to preventing HIV infection. Immunological correlates, mainly including CD4(+) T cell responses to the H...

Subject

Antibody

Immunology

Vaccine trial

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