Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region

Lesch, Klaus‐Peter; Bengel, Dietmar; Heils, Armin; Z. Sabol, Sue; D. Greenberg, Benjamin; Petri, Susanne; Benjamin, Jonathan; R. Müller, Clemens; H. Hamer, Dean; L. Murphy, Dennis

doi:10.1126/science.274.5292.1527

Public

Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region

Published in Science • Nov 29, 1996

Authors:

Klaus‐Peter Lesch

Dietmar Bengel

Armin Heils

Abstract

Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated in anxiety in humans and animal models and is the site of action of widely used uptake-inhibiting antidepressant and antianxiety drugs. Human 5-HT transporter (5-HTT) gene transcription is modulated by a co...

Subject

Serotonin transporter

Biology

Gene

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