A Phase I/II Clinical Trial in Localized Prostate Cancer of an Adenovirus Expressing Nitroreductase with CB1984

Patel, Prashant; Young, Joanna; Mautner, Vivien; Ashdown, Daniel; Bonney, Sarah; G. Pineda, Robert; I. Collins, Stuart; F. Searle, Peter; Hull, Diana; Peers, Elizabeth; Chester, John; Michael A. Wallace, D.; Doherty, Alan; Y. Leung, Hing; S. Young, Lawrence; D. James, Nicholas

doi:10.1038/mt.2009.80

Public

A Phase I/II Clinical Trial in Localized Prostate Cancer of an Adenovirus Expressing Nitroreductase with CB1984

Published in Molecular Therapy • Apr 14, 2009

Authors:

Prashant Patel

Joanna Young

Vivien Mautner

Abstract

We report a phase I/II clinical trial in prostate cancer (PCa) using direct intraprostatic injection of a replication defective adenovirus vector (CTL102) encoding bacterial nitroreductase (NTR) in conjunction with systemic prodrug CB1954. One group of patients with localized PCa scheduled for radic...

Subject

Nitroreductase

Prostate cancer

Prostate

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