The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction

P. Jackson, Andrew; D. Otto, Thomas; C. Darby, Alistair; Ramaprasad, Abhinay; Xia, D.; Echaide, Ignacio; Farber, Marisa; Gahlot, Surbhi; Gamble, John; Gupta, Dinesh; Gupta, Yakhlesh; A. Jackson, Louise; Malandrin, Laurence; B. Malas, Tareq; M. Moussa, Ehab; G. Nair, Meera; J. Reid, Adam; Sanders, Mandy; Sharma, Jyotsna; Tracey, Alan; A. Quail, Michael; Weir, William; M. Wastling, Jonathan; Hall, Neil; Willadsen, Peter; Lingelbach, Klaus; Shiels, Brian; Tait, A.; Berriman, Matthew; R. Allred, David; Pain, Arnab

doi:10.1093/nar/gku322

Public

The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction

Published in Nucleic Acids Research • May 5, 2014

Authors:

Andrew P. Jackson

Thomas D. Otto

Alistair C. Darby

Abstract

Babesia spp. are tick-borne, intraerythrocytic hemoparasites that use antigenic variation to resist host immunity, through sequential modification of the parasite-derived variant erythrocyte surface antigen (VESA) expressed on the infected red blood cell surface. We identified the genomic processes ...

Subject

Biology

Antigenic variation

Babesia bovis

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