Treatment of Invasive Aspergillosis with Posaconazole in Patients Who Are Refractory to or Intolerant of Conventional Therapy: An Externally Controlled Trial

J. Walsh, Thomas; Raad, Issam; F. Patterson, Thomas; Chandrasekar, Pranatharthi; R. Donowitz, Gerald; Graybill, Richard; E. Greene, Reginald; Hachem, Ray; Hadley, Susan; Herbrecht, Raoul; Langston, Amelia; Louie, Arnold; Ribaud, Patricia; H. Segal, Brahm; A. Stevens, David; H. van Burik, Jo‐Anne; S. White, Charles; Corcoran, Gavin; Gogate, Jagadish; Krishna, Gopal; D. Pedicone, Lisa; Hardalo, C.; R. Perfect, John

doi:10.1086/508774

Public

Treatment of Invasive Aspergillosis with Posaconazole in Patients Who Are Refractory to or Intolerant of Conventional Therapy: An Externally Controlled Trial

Published in Clinical Infectious Diseases • Dec 1, 2006

Authors:

Thomas J. Walsh

Issam Raad

Thomas F. Patterson

Abstract

BACKGROUND: Invasive aspergillosis is an important cause of morbidity and mortality in immunocompromised patients. Current treatments provide limited benefit. Posaconazole is an extended-spectrum triazole with in vitro and in vivo activity against Aspergillus species. METHODS: We investigated the ef...

Subject

Posaconazole

Medicine

Aspergillosis

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