Pediatric-Inspired Therapy in Adults With Philadelphia Chromosome–Negative Acute Lymphoblastic Leukemia: The GRAALL-2003 Study

Huguet, Françoise; Leguay, Thibaut; Raffoux, Emmanuel; Thomas, Xavier; Beldjord, Kheïra; Delabesse, Éric; Chevallier, Patrice; Buzyn, Agnès; Delannoy, André; Chalandon, Yves; Vernant, Jean‐Paul; Lafage‐Pochitaloff, Mårina; Chassevent, Agnès; Lhéritier, Véronique; Macintyre, Elizabeth; C. Béné, Marie; Ifrah, Norbert; Dombret, Hervé

doi:10.1200/jco.2008.18.6916

Public

Pediatric-Inspired Therapy in Adults With Philadelphia Chromosome–Negative Acute Lymphoblastic Leukemia: The GRAALL-2003 Study

Published in Journal of Clinical Oncology • Jan 5, 2009

Authors:

Françoise Huguet

Thibaut Leguay

Emmanuel Raffoux

Abstract

PURPOSE: Retrospective comparisons have suggested that adolescents or teenagers with acute lymphoblastic leukemia (ALL) benefit from pediatric rather than adult chemotherapy regimens. Thus, the aim of the present phase II study was to test a pediatric-inspired treatment, including intensified doses ...

Subject

Medicine

Lymphoblastic Leukemia

Philadelphia chromosome

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