Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

S. Dimas, Antigone; Lagou, Vasiliki; Barker, Adam; W. Knowles, Joshua; Mägi, Reedik; Hivert, Marie‐France; Benazzo, Andrea; Rybin, Denis; Jackson, Anne; M. Stringham, Heather; Song, Ci; Fischer‐Rosinsky, Antje; Welløv Boesgaard, Trine; Grarup, Niels; Abbasi, Fahim; L. Assimes, Themistocles; Hao, Ke; Yang, Xia; Lecœur, Cécile; Barroso, Inês; L. Bonnycastle, Lori; Böttcher, Yvonne; Bumpstead, Suzannah; S. Chines, Peter; R. Erdos, Michael; Graessler, J.; Kovács, Péter; A. Morken, Mario; Narisu, Narisu; Payne, Felicity; Stančáková, Alena; J. Swift, Amy; Tönjes, Anke; R. Bornstein, Stefan; Cauchi, Stéphane; Froguel, Philippe; Meyre, David; E. H. Schwarz, Peter; Häring, Hans‐Ulrich; Smith, Ulf; Boehnke, Michael; N. Bergman, Richard; S. Collins, Francis; L. Mohlke, Karen; Tuomilehto, Jaakko; Quertemous, Thomas; Lind, Lars; Hansen, Torben; Pedersen, Oluf; Walker, Mark; Pfeiffer, Andreas; Spranger, Joachim; Stümvoll, Michael; B. Meigs, James; J. Wareham, Nicholas; Kuusisto, Johanna; Laakso, Markku; Langenberg, Claudia; Dupuis, Josée; M. Watanabe, Richard; C. Florez, José; Ingelsson, Erik; I. McCarthy, Mark; Prokopenko, Inga; behalf of the MAGIC Investigators, on

doi:10.2337/db13-0949

Public

Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

Published in Diabetes • Dec 3, 2013

Authors:

Antigone S. Dimas

Vasiliki Lagou

Adam Barker

Abstract

Patients with established type 2 diabetes display both β-cell dysfunction and insulin resistance. To define fundamental processes leading to the diabetic state, we examined the relationship between type 2 diabetes risk variants at 37 established susceptibility loci, and indices of proinsulin process...

Subject

Type 2 diabetes

Glycemic

Genetic heterogeneity

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