Substrate Specificities of MexAB-OprM, MexCD-OprJ, and MexXY-OprM Efflux Pumps in <i>Pseudomonas aeruginosa</i>

Masuda, Nobuhisa; Sakagawa, Eiko; Ohya, Satoshi; Gotoh, Naomasa; Tsujimoto, Hideto; Nishino, Takeshi

doi:10.1128/aac.44.12.3322-3327.2000

Public

Substrate Specificities of MexAB-OprM, MexCD-OprJ, and MexXY-OprM Efflux Pumps in Pseudomonas aeruginosa

Published in Antimicrobial Agents and Chemotherapy • Dec 1, 2000

Authors:

Nobuhisa Masuda

Eiko Sakagawa

Satoshi Ohya

Abstract

To find the exact substrate specificities of three species of tripartite efflux systems of Pseudomonas aeruginosa, MexAB-OprM, MexCD-OprJ, and MexXY-OprM, we constructed a series of isogenic mutants, each of which constitutively overproduced one of the three efflux systems and lacked the other two, ...

Subject

Cefsulodin

Carbenicillin

Microbiology

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