Limitation of Excessive Extracellular Matrix Turnover May Contribute to Survival Benefit of Spironolactone Therapy in Patients With Congestive Heart Failure

Zannad, Faı̈ez; Alla, François; Dousset, Brigitte; Pérez Pérez, A.J.; Pitt, Bertram

doi:10.1161/01.cir.102.22.2700

Public

Limitation of Excessive Extracellular Matrix Turnover May Contribute to Survival Benefit of Spironolactone Therapy in Patients With Congestive Heart Failure

Published in Circulation • Nov 28, 2000

Authors:

Faı̈ez Zannad

François Alla

Brigitte Dousset

Abstract

BACKGROUND: In congestive heart failure (CHF), extracellular matrix turnover is a major determinant of cardiac remodeling. It has been suggested that spironolactone may decrease cardiac fibrosis. We investigated the interactions between serum markers of cardiac fibrosis and the effect of spironolact...

Subject

Spironolactone

Medicine

Heart failure

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