Activation of Jak2 Catalytic Activity Requires Phosphorylation of Y 1007 in the Kinase Activation Loop

The Janus protein tyrosine kinases (Jaks) play critical roles in transducing growth and differentiation signals emanating from ligand-activated cytokine receptor complexes. The activation of the Jaks is hypothesized to occur as a consequence of auto- or transphosphorylation on tyrosine residues asso... View More