Coupling of Hormonal Stimulation and Transcription via the Cyclic AMP-Responsive Factor CREB Is Rate Limited by Nuclear Entry of Protein Kinase A

Hagiwara, Masatoshi; K. Brindle, Paul; Harootunian, A.; Armstrong, Robert; Rivier, Jean; Vale, Wylie; Y. Tsien, Roger; Montminy, Marc

doi:10.1128/mcb.13.8.4852-4859.1993

Public

Coupling of Hormonal Stimulation and Transcription via the Cyclic AMP-Responsive Factor CREB Is Rate Limited by Nuclear Entry of Protein Kinase A

Published in Molecular and Cellular Biology • Aug 1, 1993

Authors:

Masatoshi Hagiwara

Paul K. Brindle

A. Harootunian

Abstract

Cyclic AMP (cAMP) regulates a number of eukaryotic genes by mediating the protein kinase A (PKA)-dependent phosphorylation of the CREB transcription factor at Ser-133. In this study, we test the hypothesis that the stoichiometry and kinetics of CREB phosphorylation are determined by the liberation a...

Subject

CREB

Phosphorylation

Biology

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