Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs

Sheng Chen, Tian; Arslan, Fatih; Yin, Yijun; Sim Tan, Soon; Chai Lai, Ruenn; Choo, Andre; Padmanabhan, Jayanthi; Neng Lee, Chuen; PV de Kleijn, Dominique; Kiang Lim, Sai

doi:10.1186/1479-5876-9-47

Public

Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs

Published in Journal of Translational Medicine • Apr 25, 2011

Authors:

Tian Sheng Chen

Fatih Arslan

Yijun Yin

Abstract

BACKGROUND: Exosomes or secreted bi-lipid vesicles from human ESC-derived mesenchymal stem cells (hESC-MSCs) have been shown to reduce myocardial ischemia/reperfusion injury in animal models. However, as hESC-MSCs are not infinitely expansible, large scale production of these exosomes would require ...

Subject

Mesenchymal stem cell

Microvesicles

Transgene

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