Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease

J. Pirola, Carlos; Fernández Gianotti, Tomas; L. Burgueño, Adriana; Rey‐Funes, Manuel; Fabián Loidl, César; Mallardi, Pablo; San Martino, Julio; Castaño, Gustavo; Sookoian, Silvia

doi:10.1136/gutjnl-2012-302962

Public

Epigenetic modification of liver mitochondrial DNA is associated with histological severity of nonalcoholic fatty liver disease

Published in Gut • Aug 9, 2012

Authors:

Carlos J. Pirola

Tomas Fernández Gianotti

Adriana L. Burgueño

Abstract

OBJECTIVE & DESIGN: Nonalcoholic fatty liver disease (NAFLD) is a clinical condition that refers to progressive histological changes ranging from simple steatosis (SS) to nonalcoholic steatohepatitis (NASH). We evaluated the status of cytosine methylation (5mC) of liver mitochondrial DNA (mtDNA) in ...

Subject

Nonalcoholic fatty liver disease

Fatty liver

DNA methylation

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