Epigenetic Gene Promoter Methylation at Birth Is Associated With Child’s Later Adiposity

M. Godfrey, Keith; Sheppard, Allan; D. Gluckman, Peter; A. Lillycrop, Karen; C. Burdge, Graham; McLean, Cameron; Rodford, Joanne; Slater-Jefferies, J.L.; Garratt, Emma; Crozier, Sarah; Starling Emerald, Bright; R. Galé, Catharine; Inskip, Hazel; Cooper, Cyrus; A. Hanson, Mark

doi:10.2337/db10-0979

Public

Epigenetic Gene Promoter Methylation at Birth Is Associated With Child’s Later Adiposity

Published in Diabetes • Apr 7, 2011

Authors:

Keith M. Godfrey

Allan Sheppard

Peter D. Gluckman

Abstract

OBJECTIVE: Fixed genomic variation explains only a small proportion of the risk of adiposity. In animal models, maternal diet alters offspring body composition, accompanied by epigenetic changes in metabolic control genes. Little is known about whether such processes operate in humans. RESEARCH DESI...

Subject

Methylation

DNA methylation

Epigenetics

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