Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand

Hsu, Hailing; L. Lacey, David; R. Dunstan, Colin; Solovyev, Irina; Colombero, Anne; Timms, Emma; Tan, Hong‐Lin; Elliott, Gary; J. Kelley, Michael; Sarosi, Ildiko; Wang, Ling; Xia, Xing-Zhong; Elliott, Robin; Chiu, Laura; Black, Tabitha; Scully, Sheila; Capparelli, Casey; Morony, Sean; Shimamoto, Grant; Bass, Michael; J. Boyle, William

doi:10.1073/pnas.96.7.3540

Public

Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand

Published in Proceedings of the National Academy of Sciences • Mar 30, 1999

Authors:

Hailing Hsu

David L. Lacey

Colin R. Dunstan

Abstract

A receptor that mediates osteoprotegerin ligand (OPGL)-induced osteoclast differentiation and activation has been identified via genomic analysis of a primary osteoclast precursor cell cDNA library and is identical to the tumor necrosis factor receptor (TNFR) family member RANK. The RANK mRNA was hi...

Subject

Osteoclast

RANK Ligand

Osteoprotegerin

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