Phase III Trial of Infusional Fluorouracil, Leucovorin, Oxaliplatin, and Irinotecan (FOLFOXIRI) Compared With Infusional Fluorouracil, Leucovorin, and Irinotecan (FOLFIRI) As First-Line Treatment for Metastatic Colorectal Cancer: The Gruppo Oncologico Nord Ovest

Falcone, Alfredo; Ricci, Sergio; Brunetti, I.; Pfanner, E.; Allegrini, Giacomo; Barbara, C.; Crinò, Lucio; Benedetti, Giovanni; Evangelista, W.; Fanchini, Laura; Cortesi, Enrico; Picone, V.; Vitello, S.; Chiara, Silvana; Granetto, Cristina; Porcile, Gianfranco; Fioretto, Luisa; Orlandini, Cinzia; Andreuccetti, M.; Masi, Gianluca

doi:10.1200/jco.2006.09.0928

Public

Phase III Trial of Infusional Fluorouracil, Leucovorin, Oxaliplatin, and Irinotecan (FOLFOXIRI) Compared With Infusional Fluorouracil, Leucovorin, and Irinotecan (FOLFIRI) As First-Line Treatment for Metastatic Colorectal Cancer: The Gruppo Oncologico Nord Ovest

Published in Journal of Clinical Oncology • Apr 30, 2007

Authors:

Alfredo Falcone

Sergio Ricci

I. Brunetti

Abstract

PURPOSE: The Gruppo Oncologico Nord Ovest (GONO) conducted a phase III study comparing fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI [irinotecan 165 mg/m2 day 1, oxaliplatin 85 mg/m2 day 1, leucovorin 200 mg/m2 day 1, fluorouracil 3,200 mg/m2 48-hour continuous infusion starting o...

Subject

Medicine

FOLFIRI

Irinotecan

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