Overexpression of Aurora-A Contributes to Malignant Development of Human Esophageal Squamous Cell Carcinoma

Tong, Tong; Zhong, Yali; Kong, Jianping; Dong, Lijia; Song, Yongmei; Fu, Ming; Liu, Zhihua; Wang, Ming‐Rong; Guo, Liping; Lu, Shixin; Wu, Ming; Zhan, Qimin

doi:10.1158/1078-0432.ccr-04-0806

Public

Overexpression of Aurora-A Contributes to Malignant Development of Human Esophageal Squamous Cell Carcinoma

Published in Clinical Cancer Research • Nov 1, 2004

Authors:

Tong Tong

Yali Zhong

Jianping Kong

Abstract

PURPOSE: Aurora-A/STK15/BTAK, a centrosome-associated oncogenic protein, is implicated in the control of mitosis. Overexpression of Aurora-A has been shown to result in chromosomal aberration and genomic instability. Multiple lines of evidence indicate that Aurora-A induces cell malignant transforma...

Subject

Esophageal squamous cell carcinoma

Basal cell

Cancer research

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