The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint

Hauf, Silke; W. Cole, Richard; LaTerra, Sabrina; L. Zimmer, Christine; Schnapp, Gisela; Walter, Rainer; Heckel, Armin; Van Meel, Jacques; L. Rieder, Conly; Peters, Jan‐Michael

doi:10.1083/jcb.200208092

Public

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint

Published in The Journal of Cell Biology • Apr 21, 2003

Authors:

Silke Hauf

Richard W. Cole

Sabrina LaTerra

Abstract

The proper segregation of sister chromatids in mitosis depends on bipolar attachment of all chromosomes to the mitotic spindle. We have identified the small molecule Hesperadin as an inhibitor of chromosome alignment and segregation. Our data imply that Hesperadin causes this phenotype by inhibiting...

Subject

Kinetochore

Spindle checkpoint

Biology

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