Disruption of the neurexin 1 gene is associated with schizophrenia

Rujescu, Dan; Ingason, Andrés; Cichon, Sven; Pietiläinen, Olli; R. Barnes, Michael; Toulopoulou, Timothea; Picchioni, Marco; Vassos, Evangelos; Ettinger, Ulrich; Bramon, Elvira; Murray, Robin; Ruggeri, Mirella; Tosato, Sarah; Bonetto, Chiara; Steinberg, Stacy; Sigurðsson, Engilbert; Sigmundsson, Thordur; Pétursson, Hannes; Gylfason, Arnaldur; I. Olason, Pall; Hardarsson, Gudmundur; A. Jónsdóttir, Guðrún; Gústafsson, Ómar; Fossdal, Ragnheiður; Giegling, Ina; Möller, Hans‐Jürgen; M. Hartmann, Annette; Hoffmann, Per; Crombie, Caroline; Fraser, Gillian; Walker, Nicholas; Lönnqvist, Jouko; Suvisaari, Jaana; Tuulio‐Henriksson, Annamari; Djurovic, Srdjan; Melle, Ingrid; A. Andreassen, Ole; Folkmann Hansen, Thomas; Werge, Thomas; A. Kiemeney, Lambertus; Franke, Barbara; A. Veltman, Joris; E. Buizer‐Voskamp, Jacobine; Investigators, GROUP; Sabatti, Chiara; A. Ophoff, Roel; Rietschel, Marcella; M. Nöthen, Markus; Stefánsson, Kāri; Peltonen, Leena; St Clair, David; Stefánsson, Hreinn; Collier, David

doi:10.1093/hmg/ddn351

Public

Disruption of the neurexin 1 gene is associated with schizophrenia

Published in Human Molecular Genetics • Oct 22, 2008

Authors:

Dan Rujescu

Andrés Ingason

Sven Cichon

Abstract

Deletions within the neurexin 1 gene (NRXN1; 2p16.3) are associated with autism and have also been reported in two families with schizophrenia. We examined NRXN1, and the closely related NRXN2 and NRXN3 genes, for copy number variants (CNVs) in 2977 schizophrenia patients and 33 746 controls from se...

Subject

Biology

Copy-number variation

Schizophrenia (object-oriented programming)

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