PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration

Vijay Chaitanya, Ganta; Steven Alexander, J.; Prakash Babu, Phanithi

doi:10.1186/1478-811x-8-31

Public

PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration

Published in Cell Communication and Signaling • Dec 1, 2010

Authors:

Ganta Vijay Chaitanya

J. Steven Alexander

Phanithi Prakash Babu

Abstract

The normal function of poly (ADP-ribose) polymerase-1 (PARP-1) is the routine repair of DNA damage by adding poly (ADP ribose) polymers in response to a variety of cellular stresses. Recently, it has become widely appreciated that PARP-1 also participates in diverse physiological and pathological fu...

Subject

Proteases

Poly ADP ribose polymerase

Programmed cell death

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