<i>Helicobacter hepaticus</i>
                    Triggers Colitis in Specific-Pathogen-Free Interleukin-10 (IL-10)-Deficient Mice through an IL-12- and Gamma Interferon-Dependent Mechanism

C. Kullberg, Marika; M. Ward, Jerrold; L. Gorelick, Peter; Caspar, Patricia; Hieny, Sara; Cheever, Allen; Jankovic, Dragana; Sher, Alan

doi:10.1128/iai.66.11.5157-5166.1998

Public

Helicobacter hepaticus Triggers Colitis in Specific-Pathogen-Free Interleukin-10 (IL-10)-Deficient Mice through an IL-12- and Gamma Interferon-Dependent Mechanism

Shared by NobleBlocks on Nov 1, 1998 • 12:00 AM UTC

Authors:

Marika C. Kullberg

Jerrold M. Ward

Peter L. Gorelick

Abstract

ABSTRACT Mice rendered deficient in interleukin-10 (IL-10) by gene targeting (IL-10 −/− mice) develop chronic enterocolitis resembling human inflammatory bowel disease (IBD) when maintained in conventional animal facilities. However, they display a minimal and delayed intestinal inflammatory respons...

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