Molecular basis of downregulation of G-protein-coupled inward rectifying K(+) current (I(K,ACh) in chronic human atrial fibrillation: decrease in GIRK4 mRNA correlates with reduced I(K,ACh) and muscarinic receptor-mediated shortening of action potentials.

D, Dobrev; E, Graf; E, Wettwer; HM, Himmel; O, Hála; C, Doerfel; T, Christ; S, Schüler; U, Ravens

doi:10.1161/hc4601.099466

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Molecular basis of downregulation of G-protein-coupled inward rectifying K(+) current (I(K,ACh) in chronic human atrial fibrillation: decrease in GIRK4 mRNA correlates with reduced I(K,ACh) and muscarinic receptor-mediated shortening of action potentials.

Shared by NobleBlocks on Nov 1, 2001 • 12:00 AM UTC

Authors:

Dobrev D

Graf E

Wettwer E

Abstract

Background Clinical and experimental evidence suggest that the parasympathetic nervous system is involved in the pathogenesis of atrial fibrillation (AF). However, it is unclear whether changes in G-protein-coupled inward rectifying K(+) current (I(K,ACh)) contribute to chronic AF.Methods and result...

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