iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections

Janky, Rekin’s; Verfaillie, Annelien; Imrichová, Hana; Van de Sande, Bram; Standaert, Laura; Christiaens, Valerie; Hulselmans, Gert; Herten, Koen; Naval-Sánchez, Marina; Potier, Delphine; Svetlichnyy, Dmitry; Kalender Atak, Zeynep; Fiers, Mark; Marine, Jean‐Christophe; Aerts, Stein

doi:10.1371/journal.pcbi.1003731

Public

iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections

Published in PLoS Computational Biology • Jul 24, 2014

Authors:

Rekin’s Janky

Annelien Verfaillie

Hana Imrichová

Abstract

Identifying master regulators of biological processes and mapping their downstream gene networks are key challenges in systems biology. We developed a computational method, called iRegulon, to reverse-engineer the transcriptional regulatory network underlying a co-expressed gene set using cis-regula...

Subject

ENCODE

Computational biology

Gene regulatory network

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