FOXP3+ Regulatory T Cells Affect the Development and Progression of Hepatocarcinogenesis

Kobayashi, Noritoshi; Hiraoka, Nobuyoshi; Yamagami, Wataru; Ojima, Hidenori; Kanai, Yae; Kosuge, Tomoo; Nakajima, Atsushi; Hirohashi, Setsuo

doi:10.1158/1078-0432.ccr-06-2363

Public

FOXP3+ Regulatory T Cells Affect the Development and Progression of Hepatocarcinogenesis

Published in Clinical Cancer Research • Feb 1, 2007

Authors:

Noritoshi Kobayashi

Nobuyoshi Hiraoka

Wataru Yamagami

Abstract

PURPOSE: Tumor-infiltrating lymphocytes represent the host immune response to cancer. CD4+CD25+FOXP3+ regulatory T cells (Tregs) suppress the immune reaction. The aim of the present study was to investigate the clinicopathologic significance and roles of Tregs and CD8+ T cells during hepatocarcinoge...

Subject

FOXP3

Hepatocellular carcinoma

Immune system

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