Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

M. Van Allen, Eliezer; Miao, Diana; Schilling, Bastian; A. Shukla, Sachet; U. Blank, Christian; Zimmer, Lisa; Sucker, Antje; Hillen, Uwe; H. Geukes Foppen, Marnix; M. Goldinger, Simone; Utikal, Jochen; C. Hassel, Jessica; Weide, Benjamin; C. Kaehler, Katharina; Loquai, Carmen; Mohr, Peter; Gutzmer, Ralf; Dummer, Reinhard; Gabriel, Stacey; J. Wu, Catherine; Schadendorf, Dirk; A. Garraway, Levi

doi:10.1126/science.aad0095

Public

Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

Published in Science • Sep 11, 2015

Authors:

Eliezer M. Van Allen

Diana Miao

Bastian Schilling

Abstract

Monoclonal antibodies directed against cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), such as ipilimumab, yield considerable clinical benefit for patients with metastatic melanoma by inhibiting immune checkpoint activity, but clinical predictors of response to these therapies remain incomplet...

Subject

Ipilimumab

CTLA-4

Immune checkpoint

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