Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

P. Olive, Kenneth; A. Jacobetz, Michael; J. Davidson, Christian; Gopinathan, Aarthi; McIntyre, Dominick; Honess, Davina; Madhu, Basetti; A. Goldgraben, Mae; E. Caldwell, Meredith; Allard, David; K. Frese, Kristopher; DeNicola, Gina; Feig, Christine; Combs, Chelsea; P. Winter, Stephen; Ireland-Zecchini, Heather; Reichelt, Stefanie; J. Howat, William; Chang, Alex; Dhara, Mousumi; Wang, Lifu; Rückert, Felix; Grützmann, Robert; Pilarsky, Christian; Izeradjene, Kamel; R. Hingorani, Sunil; Huang, Pearl; E. Davies, Susan; Plunkett, William; Egorin, Merrill; H. Hruban, Ralph; Whitebread, Nigel; McGovern, Karen; Adams, Julian; Iacobuzio-Donahue, Christine; Griffiths, John; A. Tuveson, David

doi:10.1126/science.1171362

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Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

Shared by NobleBlocks on Jun 12, 2009 • 12:00 AM UTC

Authors:

Kenneth P. Olive

Michael A. Jacobetz

Christian J. Davidson

Abstract

It's All in the Delivery Pancreatic cancer is almost universally associated with a poor prognosis, in part because the tumors are resistant to chemotherapeutic drugs. Working with a mouse tumor model that displays many features of the human disease, Olive et al. (p. 1457 , published online 21 May; s...

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