Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.

P Olive, Kenneth; A Jacobetz, Michael; J Davidson, Christian; Gopinathan, Aarthi; McIntyre, Dominick; Honess, Davina; Madhu, Basetti; A Goldgraben, Mae; E Caldwell, Meredith; Allard, David; K Frese, Kristopher; Denicola, Gina; Feig, Christine; Combs, Chelsea; P Winter, Stephen; Ireland-Zecchini, Heather; Reichelt, Stefanie; J Howat, William; Chang, Alex; Dhara, Mousumi; Wang, Lifu; Rückert, Felix; Grützmann, Robert; Pilarsky, Christian; Izeradjene, Kamel; R Hingorani, Sunil; Huang, Pearl; E Davies, Susan; Plunkett, William; Egorin, Merrill; H Hruban, Ralph; Whitebread, Nigel; McGovern, Karen; Adams, Julian; Iacobuzio-Donahue, Christine; Griffiths, John; A Tuveson, David

doi:10.1126/science.1171362

Public

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.

Published in Science (New York, N.Y.) • Jun 12, 2009

NobleIDark:/48914/w1/20260526/79D7AE0DRecord on NobleID

Authors:

Kenneth P Olive

,

Michael A Jacobetz

,

Christian J Davidson

Abstract

Pancreatic ductal adenocarcinoma (PDA) is among the most lethal human cancers in part because it is insensitive to many chemotherapeutic drugs. Studying a mouse model of PDA that is refractory to the clinically used drug gemcitabine, we found that the tumors in this model were poorly perfused and po...

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