Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

P. Olive, Kenneth; A. Jacobetz, Michael; J. Davidson, Christian; Gopinathan, Aarthi; J. O. McIntyre, Dominick; J. Honess, Davina; Madhu, Basetti; A. Goldgraben, Mae; E. Caldwell, Meredith; Allard, David; K. Frese, Kristopher; M. DeNicola, Gina; Feig, Christine; Combs, Chelsea; P. Winter, Stephen; Ireland‐Zecchini, Heather; Reichelt, Stefanie; Howat, William; Chang, Alex; Dhara, Mousumi; Wang, Lifu; Rückert, Felix; Grützmann, Robert; Pilarsky, Christian; Izeradjene, Kamel; R. Hingorani, Sunil; S. Huang, Pearl; Davies, Susan; Plunkett, William; J. Egorin, Merrill; H. Hruban, Ralph; Whitebread, Nigel; McGovern, Karen; Adams, Julian; A. Iacobuzio–Donahue, Christine; R. Griffiths, John; A. Tuveson, David

doi:10.1126/science.1171362

Public

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

Published in Science • May 21, 2009

Authors:

Kenneth P. Olive

Michael A. Jacobetz

Christian J. Davidson

Abstract

Pancreatic ductal adenocarcinoma (PDA) is among the most lethal human cancers in part because it is insensitive to many chemotherapeutic drugs. Studying a mouse model of PDA that is refractory to the clinically used drug gemcitabine, we found that the tumors in this model were poorly perfused and po...

Subject

Gemcitabine

Pancreatic cancer

Hedgehog

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