Receptor-Specific Regulation of Phosphatidylinositol 3′-Kinase Activation by the Protein Tyrosine Phosphatase Shp2

Qing Zhang, Si; G. Tsiaras, William; Araki, Toshiyuki; Wen, Gengyun; Minichiello, Liliana; Klein, Rüdiger; G. Neel, Benjamin

doi:10.1128/mcb.22.12.4062-4072.2002

Public

Receptor-Specific Regulation of Phosphatidylinositol 3′-Kinase Activation by the Protein Tyrosine Phosphatase Shp2

Published in Molecular and Cellular Biology • Jun 1, 2002

Authors:

Si Qing Zhang

William G. Tsiaras

Toshiyuki Araki

Abstract

Receptor tyrosine kinases (RTKs) play distinct roles in multiple biological systems. Many RTKs transmit similar signals, raising questions about how specificity is achieved. One potential mechanism for RTK specificity is control of the magnitude and kinetics of activation of downstream pathways. We ...

Subject

Biology

Protein tyrosine phosphatase

Cell biology

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