PD‐1 and PD‐L1 upregulation promotes CD8<sup>+</sup> T‐cell apoptosis and postoperative recurrence in hepatocellular carcinoma patients

Shi, Feng; Shi, Ming; Zeng, Zhen; Qi, Ruizhao; Liu, Zhen‐Wen; Zhang, Ji‐Yuan; Yang, Yongping; Tien, Po; Wang, Fu‐Sheng

doi:10.1002/ijc.25397

Public

PD‐1 and PD‐L1 upregulation promotes CD8+ T‐cell apoptosis and postoperative recurrence in hepatocellular carcinoma patients

Published in International Journal of Cancer • Apr 19, 2010

Authors:

Feng Shi

Ming Shi

Zhen Zeng

Abstract

Programmed death 1 (PD-1) and its ligand (PD-L1) play pivotal roles in regulating host immune responses. However, the inhibitory effects of this pathway on the function of cytotoxic CD8(+) T lymphocytes, the main effector cells in hepatocellular carcinoma (HCC) patients, are not well defined. In thi...

Subject

Cytotoxic T cell

CD8

Cancer research

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