Globular Adiponectin Protected ob/ob Mice from Diabetes and ApoE-deficient Mice from Atherosclerosis

Yamauchi, Toshimasa; Kamon, Junji; Waki, Hironori; Imai, Yasushi; Shimozawa, Nobuhiro; Hioki, Kyouji; Uchida, Shoko; Ito, Yusuke; Takakuwa, Keisuke; Matsui, Junji; Takata, Makoto; Eto, Kazuhiro; Terauchi, Yasuo; Komeda, Kajuro; Tsunoda, Masaki; Murakami, Koji; Ohnishi, Yasuyuki; Naitoh, Takeshi; Yamamura, Ken‐ichi; Ueyama, Yoshito; Froguel, Philippe; Kimura, Satoshi; Nagai, Ryozo; Kadowaki, Takashi

doi:10.1074/jbc.m209033200

Public

Globular Adiponectin Protected ob/ob Mice from Diabetes and ApoE-deficient Mice from Atherosclerosis

Published in Journal of Biological Chemistry • Jan 1, 2003

Authors:

Toshimasa Yamauchi

Junji Kamon

Hironori Waki

Abstract

The adipocyte-derived hormone adiponectin has been shown to play important roles in the regulation of energy homeostasis and insulin sensitivity. In this study, we analyzed globular domain adiponectin (gAd) transgenic (Tg) mice crossed with leptin-deficient ob/ob or apoE-deficient mice. Interestingl...

Subject

Adiponectin

Endocrinology

Internal medicine

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