Local Translation and Retrograde Axonal Transport of CREB Regulates IL-6-Induced Nociceptive Plasticity

K. Melemedjian, Ohannes; V. Tillu, Dipti; K. Moy, Jamie; N. Asiedu, Marina; K. Mandell, Edward; Ghosh, Sourav; Dussor, Gregory; J. Price, Theodore

doi:10.1186/1744-8069-10-45

Public

Local Translation and Retrograde Axonal Transport of CREB Regulates IL-6-Induced Nociceptive Plasticity

Published in Molecular Pain • Jan 1, 2014

Authors:

Ohannes K. Melemedjian

Dipti V. Tillu

Jamie K. Moy

Abstract

Transcriptional regulation of genes by cyclic AMP response element binding protein (CREB) is essential for the maintenance of long-term memory. Moreover, retrograde axonal trafficking of CREB in response to nerve growth factor (NGF) is critical for the survival of developing primary sensory neurons....

Subject

CREB

Axoplasmic transport

Hyperalgesia

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!